MECHANIC OF VENTILATION

Hello. It quite a long time I didnt post anything. Well I am busy lately.
Okay without any further a due shall we start now?  whatever I will start now. NowI talked crap. Lets begin



Im just gonna write about muscles. Im too lazy to  write about anything else.

INSPIRATION
-external intercostal muscle
-diaphragm (the main muscle in inspiration)
-accessory muscle (anterior serratus,sternocleidomastoid,scalene muscle)

EXPIRATION
-internal intrrcostal muscle
-abdomal muscle ( rectus abdominis,internal & external oblique muscles,transverse muscle)

EXPERIENCE (the beginning)

me one day!

 Hi world!! May you have a good day today. 
This is quit sometimes i didn't wrote anything in my blog. This past two weeks I am quit busy. I had exam earlier that why not doing some writing. hehe.. So today I don't really have any intention to write about medical stuff. I just wanna share some of my experiences in medical world.(it is not much at all but still i wanna share) 
 So, to be honest i never thought I will take this course during my university years. It is because I wanna enjoy my college life and finish my study early then working,have my own money,married with handsome man and have lovely kids. That what I planned when i'm 17 years old. But I guess we just can plan but everything is in GOD hand. 
Now, I'm here doing medicine. My friends quit surprise when i told them i'm doing medicine. Some of them thought i'm joking. But when they know i'm serious (dead serious ) they give me full of their support. (that why i love them). 
I know GOD have reason giving this opportunity me. I accept it with open hand. even sometimes i'm wondering why. My SPM is not really good. (spm is an exam like college entrance exam) I don't get straight A's. My foundation result also not 4.00. Despite of all that, God still give me the opportunity to take medical courses.So, I'm grateful. 
When I' studying, i face many diffulties in my courses subject. especially for anatomy. I couldn't remember all those muscles. (muscles are so damn many) So I fail my first exam. I got F-. My essay is the worst amongs other paper.I got lower F for my essay. My heart feel like it is stop but i couldn't cry. ( why i dont cry because crying is uncool). i am devastated. My body feel like it is crushing. I never failed in exam before and now i already failed.
 So back to my room, i prayed to god. Asking HIM   to help me. i'm not strong enough at that time. I cried hard in my pray.Nobody will understand how it felt to be failed. I don't wanna told my mom because she won't understand too.So, i prayed to god to get some inner strength. So that night, i review back my action during before the exam and i realizes that i not really studying hard enough to get the good result. 
Every cloud has a silver lining. You may not get it now but you get it later. So for the upcoming exam i will strive harder to improve my result. I formed study group with my friends every week to discuss the previous lecture and to share our understanding. It help me to understand better. i really thank her for her help. 
So, last two week I had a second exam. and my result ,Alhamdulliah it is improve a lot. may be it is not A+ but the most important thing is........
 i PASS!! I'm so happy!!
 Im gonna kill the 3rd exam. 
I'm thank to  ALLAH for listening my pray everyday, 
I'm thanking to ALLAH for making me peace when im miserable. 
I'm thanking to ALLAH for everything. 
My life is better with HIM beside me. 

So, guys being  medical student ain't easy.be strong because you can do it. share your problem with friends and family (if you thinks they can help you) it is because we are not alone in this world. If you thinks no one can help you,nobody understand your problem, turn back to the creator. God understand everything. Take your time everyday to talk to him. it is not wasting your time. believe me it help.
if you are muslim, dont ever ever leave your prayer.

formula to success 
success = effort + pray (doa) + tawakal ( accept the result as it is) 
 I hope everyone are success in what ever they do. 
sincerely,
Aldrin

SPINOTHALAMIC TRACT

Now I would like to write about SPINOTHALAMIC TRACT. For the first time Im study this tract Im not really clear about this tract but dont worry im good now. 

For this tract there are about 10 point that you can write. ( this is as for me. if you have more then it good. the more the better). I provide a picture so you can easily imagine what the heck im writing about. 

I provide extra large picture.

 THE KEY POINT!!! 
Because I told you just now there are about 10 important point so there are also 10 important key point that will help you and me remember this tract
                          1) receptor cell bodies & first order neuron 
                          2)dorsolateral tract of Lissauer 
                          3)1st synapse
                          4)2nd order neuron cell bodies
                          5)2nd order neuron 
                          6)brainstem 
                          7)spinal leminisci
                          8)cell bodies of 3rd order neuron
                          9)2nd synapse 
                        10)termination 

There are the key point. I know you wont understand what the heck is that. Lets me write properly all  the point 
Firstly, you need to write about receptor cell bodies and first order neuron
- Receptor cell bodies located at dorsal root ganglion. Afferent fibres of first order neuron enter dorsal root ganglion. 
- Then, first order neuron will ascend or descend 1 or 2 segment known as dorsolateral tract of Lissauer
- First order neuron will synapse with second order neuron in dorsal horn of spinal cord
-Second order neuron cell bodies located at dorsal horn of spinal cord 
-Second order neuron will cross obliquely to the opposite site in the anterior gray commissure,anterior white commissure and anterolateral white column 
- Then it will ascend through brainstem 
                                lateral part to medulla oblongata
                                posterior part to pon
                                tegmentum part to midbrain
                               anterolateral part of spinal cord
-Both anterior and lateral spinothalamic tract with spinotectal tract will form spinal leminisci 
-Cell bodies of third order neuron lies at ventral posterior lateral (VPL) nucleus of thalamus 
-Second order neuron synapse with third order neuron and then fibres pass through posterior limb of internal capsule and corona radiata
-The fibres terminate at the primary somesthetic cortex




                       

VITAMIN K

Today topic is about vitamin. Specifically vitamin K. Nowadays, my friends are crazy about vitamin. So I wanna write about vitamin.

Basically, as a medical student we should know about vitamin K. Why? Because it important for blood clot

If you want to write essay about vitamin K you should consider about it function, metabolic and nutritional aspect.
You must be wondering about how to write its metabolism. When you write about metabolism, you should write about its absorption, storage.
And if you wanna write about nutritional aspect,you should write about its sources, deficiency, toxicity and its recommendations.
*or you just write whatever you want.
 LETS BEGIN

 FUNCTION
- Main function of vitamin K is helps bloot clot.
 why?
 vitamin K required for glutamatic acid to change to gamma-carboxy glutamic acid. Prothrombin, factor 7,    factor 9, factor 10 have gamma-carboxy glutamic acid in their structures.
- Vitamin K administered before operation to reduce bleeding during surgery
- Vitamin K administered to all new borns
- Vitamin K needed for making key protein for bone formation.

SOURCES
- Bacteria synthesis in the Gastrointestinal tract
-vitamin K RICH food ( liver, green leafy vegetable,member of cabbage family)
-vitamin K SMALL amount ( milk,cereal, fruit,egg)

DEFICIENCY
Deficiency of Vitamin K is unlikely. EXCEPT
-NEWBORN BABY ( why?)
because they have clean GI Tract, because inadequate stores
-PERSON THAT TAKE ANTIBIOTIC
because the bacteria have been killed by antibiotic
major symptom : haemorraging (loss of blood )

TOXICITY
high dose of vitamin K reduce the effectiveness of anticoagulant drugs

RICH IN VITAMIN K

SOME QUESTION

HI!! today I will make my post really simple.. I just wanna give a mnemonic regarding lobule of cerebellum.This is my assessment exam question. First time i saw this question, i think what the heck. i have no idea at all about any lobule. so I thought i should use my creative thinking.  
          

         Lobule of cerebellum
       A culmen                                          

       B   tonsil                                         

       C   lingual                                 

       D  uvula                                     

       E  flocculus  

you may try this question.

THIS IS THE MNEMONIC 

2CD Utama Plain white t's Faris Telah Nadia Larikan.(again sorry because i couldn't make it in english)

2C-culmen

    -central lobule

D- declive

Utama- uvula

Plain white t's- pyramis 

Faris- folium  

Telah- tuber

Nadia- nodule

Larikan- lingula 

If you think my mnemonic is not helping. well do it by yourself. be creative.till then.. bye.. 

sincerely, 

Aldrin

HEMOSTASIS

So for my next post, I would like to write about hemostasis. BE  CAREFULL!! Don't get confuse between HEMOSTASIS and HOMEOSTASIS. 

Following the free dictionary by farlex (which i found in the internet) hemostasis can be defined as the arrest of bleeding by the physiological properties of vasoconstriction and coagulation or by surgical means.(basically hemostasis is just about blood. don't need to over think about it) and homeostasis is a  tendency to equilibrium or stability in the normal physiological states of the organism ( again to make your life easier homeostasis is about body regulate)ion.) 

Ok let's begin our topic for today... 

HEMOSTASIS

Hemostasis consists of 5 components which are:
- blood vessel
-platelet
-coagulation factor
- coagulation inhibitor
- fibrinolytic system 

In my university, this topic is quit important. It's always come out in exam. So I already created a mnemonic for you and me to remember. 
BP Cik Cukup Fabulous. (sorry i couldn't think about english mnemonic) 

B- blood vessel
P- platelet
Cik- coagulation factor
Cukup- coagulation inhibitor
Fabulous- fibrinolytic system 

I won't explain any further. (sorry). but i would like to give another mnemonic regarding platelet. 
If you don't know platelet will carry on primary hemolytic plug. There are 5 components in hemolytic plug which are :
ADHESION 
SHAPE CHANGE
RELEASE REACTION 
AGGREGATION OF PLATELET
PLATELET PROCOAGULANT ACTIVITY                                               
(ASRAP)

IRON ABSORPTION

So for this post i provided  picture. ( I just figure it out a couple of minutes ago). Now i would like to write about IRON ABSORPTION. Iron is one of the important mineral rquires by our body. If our body lack of iron we may obtain anemia. Before we can talk about anemia lets know how iron can be absorbed in our body. This is the interesting process though. 

Must know fact!! 

 Iron is absorbed more efficiently at duodenum and less efficiently in jejunum.This is basic. 

•  Firstly, iron released from protein-complex by acid and proteolytic enzyme in the stomach and small intestine 
• haem also liberated from haemoglobin and myoglobin.
• Absorption may occur when iron in ferrous state (Fe2+)
• So ferric (Fe3+) will be converted into (Fe2+) by enzyme ferric reductase
• absorption of iron favour by factor such as acid and reducing agents because those factor can keep iron in Fe2+ rather than Fe3+
• Dietary iron absorb in apical membrane of mature erythrocyte 
• haem-bound iron take up by haem receptor while non-haem bound iron transported by DMT-1
• so iron either be stored within the cell as ferritin or be transported by ferroportin 
• DMT-1 protein transfer the iron from lumen of the gut across enterocyte micovilli 
• ferroportin at basolateral surface control the iron uptake from the cell into portal vein
• amount of iron depends according the body need by changing the amount of DMT-1 and ferroportin 
• HFE (human haemochromatosis protein) expressed in the crypt cell and bind with TfR(transferrin receptor). 
• It also control the amount of iron uptake by the portal vein into the cell