IRON ABSORPTION

So for this post i provided  picture. ( I just figure it out a couple of minutes ago). Now i would like to write about IRON ABSORPTION. Iron is one of the important mineral rquires by our body. If our body lack of iron we may obtain anemia. Before we can talk about anemia lets know how iron can be absorbed in our body. This is the interesting process though. 

Must know fact!! 

 Iron is absorbed more efficiently at duodenum and less efficiently in jejunum.This is basic. 

•  Firstly, iron released from protein-complex by acid and proteolytic enzyme in the stomach and small intestine 
• haem also liberated from haemoglobin and myoglobin.
• Absorption may occur when iron in ferrous state (Fe2+)
• So ferric (Fe3+) will be converted into (Fe2+) by enzyme ferric reductase
• absorption of iron favour by factor such as acid and reducing agents because those factor can keep iron in Fe2+ rather than Fe3+
• Dietary iron absorb in apical membrane of mature erythrocyte 
• haem-bound iron take up by haem receptor while non-haem bound iron transported by DMT-1
• so iron either be stored within the cell as ferritin or be transported by ferroportin 
• DMT-1 protein transfer the iron from lumen of the gut across enterocyte micovilli 
• ferroportin at basolateral surface control the iron uptake from the cell into portal vein
• amount of iron depends according the body need by changing the amount of DMT-1 and ferroportin 
• HFE (human haemochromatosis protein) expressed in the crypt cell and bind with TfR(transferrin receptor). 
• It also control the amount of iron uptake by the portal vein into the cell